Output Biosciences is pioneering Biologically-Aware Generative AI to finally understand complex biological systems. We are building Large Biological Models that can generate breakthrough medicines and transform the way we diagnose, treat and prevent disease. Output was founded by Adi Mashiach, MD and Mirella Mashiach. Adi is third time founder of AI-driven biotech startups (first was acquired, second is on Nasdaq), a former physician and researcher in computational systems biology focused on nonlinear dynamics; Mirella is a former big pharma exec and biotech investor.

The Role

Join our team and help build the world's first biological reasoning model. Work with us to build generative foundational models that decode biological systems across scales — from molecules to organisms — enabling us to predict, understand, and program living systems in ways never before possible.

Output Biosciences is currently in stealth, operated by a team of repeat founders and biotech veterans with multiple exits in AI and biology, and backed by top VCs including Y Combinator.

As a Machine Learning Research Scientist, Interpretability, you'll work alongside our founders and team members to develop AI systems capable of processing and reasoning across multiple biological data modalities simultaneously.

• You will develop specialized methods for understanding our biological reasoning models, reverse-engineering how they represent and process complex biological information.
• You will design and conduct experiments to uncover interpretable features across biological scales.
• You will address unique challenges in biological model interpretation, such as disentangling the multi-scale, hierarchical representations of biological systems 
• You will build biology-specific visualization tools that can map model activations to meaningful biological concepts.

Who We're Looking For:

• You have a Bachelor's degree in Computer Science, Computer Engineering, Mathematics, Physics, or a relevant technical field.
• You have a PhD with 2 years of research experience, or a Bachelor's degree with 4+ years of research or industry experience in Deep Learning, Artificial Intelligence, or other relevant fields.
• You have a strong publication record in top-tier AI conferences or journals (e.g., NeurIPS, ICML, ICLR).
• You are proficient in Python and have expertise in at least one major deep learning framework (PyTorch, TensorFlow, or JAX).

Who You Are:

• You have excellent problem-solving skills and the ability to quickly adapt to new challenges.
• You exhibit a proactive approach to problem-solving, thinking beyond the specific task, taking ownership of challenges, and taking pride in solving them.
• You have a mature mindset in ambiguous situations, helping to frame questions and seek clarity while making decisions in the face of uncertainty.
• You have excellent communication skills and can clearly articulate complex technical concepts.
• You are motivated by making a real impact and are committed to tackling problems of significant consequence with determination and creativity.

Bonus points:

• You have experience applying machine learning to biological or chemical problems.
• You have knowledge of physics, molecular biology, chemistry, computational biology, bioinformatics, cheminformatics, or related fields.
• You have experience with multi-modal learning.
• You have contributed to open-source machine learning projects/
• You have experience in developing efficient code in C/C++.

Our Values

❤️ Heart: We foster a culture of ownership. We are assembling a team of individuals who are passionate and take pride in their contributions.

🏆 Excellence: We have an unwavering commitment to excellence and continuously challenge ourselves to reach the highest standards.

🚀 Practicality: We value practicality and results-oriented thinking. We are committed to making a tangible impact on the lives of our patients and the broader community.

📣 Honesty: We place a high value on honesty and directness. We firmly believe in addressing issues as they arise, in an open and transparent manner.

🎮 Fun: We believe that life is too short to not have fun. That's why we're committed to creating an engaging and enjoyable work environment. Our goal is to create a workplace that is fun, rewarding and fulfilling.

What We Offer

• We encourage new and different ideas, creativity and contrarian thinking.
• You own your day-to-day management. What we care about is that we all hit our milestones.
• Competitive salary and equity in a growing, well-funded startup
• Excellent medical, dental, and vision coverage
• Healthy feedback focused environment to help you strive - leadership will have high expectations, regularly share constructive feedback, support you and help you grow, and welcome receiving feedback and ideas from you
• We are looking forward to further shaping our culture with early team members. You'll have a chance to make your mark!