Senior Scientist - NGS Assay Development at BillionToOne (S17)
The genetic testing platform detecting and measuring disease.
Menlo Park, CA
Any (new grads ok)
About BillionToOne

BillionToOne has developed a DNA molecular counter that increases the cell-free DNA diagnostics resolution by over 1,000 fold. We are the only technology platform that can detect single-gene disorders in an unborn baby from maternal blood and that can accurately quantify copy number variation (CNV) changes in cancer patients. Our first product, UNITY, is the only NIPT that accurately detects single gene disorders such as cystic fibrosis and sickle cell in the baby from a blood test of the mother. UNITY covers all inherited disorders that every pregnancy needs to be tested for and has 98.5%+ sensitivity and 99%+ specificity.

BillionToOne has recently raised a large Series A funding from global institutional investors, including from Hummingbird Ventures, NeoTribe Ventures and Y Combinator:

Check out a simplified introduction to our technology and its potential to transform molecular diagnostics:

About the role
Skills: Gene sequencing, Molecular biology, Genomics, Next generation sequencing

Do you want to join one of the fastest-growing molecular diagnostics companies to transform prenatal and oncology diagnostics that can affect millions of patient lives?

BillionToOne is looking for a Senior Scientist to enhance our development team responsible for driving innovative next-gen sequencing, robotic automation, and bioinformatics solutions to our high-growth clinical laboratory. This is an extremely impactful scientist role who will own nucleic acid biochemistry improvements as we scale our clinical laboratory another 10x in the next 2-3 years.


  • Lead NGS library prep improvements as a part of laboratory scaling efforts, in collaboration with robotics automation and bioinformatics
  • Provide expert technical judgement for CLIA laboratory processes including, but not limited to, process validations and the transfer of new methodologies to clinical operations.
  • Design experiments to validate new diagnostic/screening assays, procedure changes, and instruments.
  • Collaborate with the clinical and other R&D teams to transfer new products and procedures into the CLIA laboratory

Who You Are

  • PhD in biological sciences, chemistry, bioengineering, biophysics, or related discipline with extensive molecular biology lab experience
  • Very strong intuition and first-principles approach to molecular biology assays, analytical chemistry tools, and NGS library prep (PCR, DNA purification, electrophoresis, etc.)
  • Strong ability to analyze high-throughput experimental data (e.g. in python or R) to iterate and refine experiment design.
  • Stellar written technical communication, project management, and organizational skills


  • Start-up experience
  • Ability to analyze NGS data using common bioinformatics tools (e.g. bwa mem, GATK, etc.)
  • Laboratory automation experience
  • Experience working under regulatory environments such as CLIA, CAP, or FDA

Software tech stack

  • Python
  • Django / django rest framework
  • Postgres
  • Heroku

DNA sequencing tech stack

  • Illumina high throughput sequencing
  • Sanger sequencing
  • PCR
  • Genome Analysis Toolkit / samtools / bedtools
  • AWS

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