Circumvent (S18)
Utilizing monogenic disorders to inform and solve highly complex disorders such as neurodegenerative disease

Research Scientist/Program Manager

Remote
Full-time
3+ years
About Circumvent

Circumvent Pharmaceuticals has built an experienced team of scientists and clinicians to focus on the clinical development of a small molecule therapy for the orphan disease, CLN1 Batten. This is a fatal pediatric disease caused by aberrant levels of protein palmitoylation, a reversible modification of cysteine. Palmitoylation is a common post-translational modification that can regulate protein localization, interaction and function. Circumvent is dedicated to the treatment of Batten disease, the effects of which are most pronounced in the lysosomes of neurons. Other diseases that lead to neurodegeneration may also benefit from a treatment that leads to normalization of palmitoylation levels, such as Alzheimer’s, Parkinson’s, Huntington’s and ALS and are of great interest to the company.

About the role

Circumvent Pharmaceuticals has built an experienced team of scientists and clinicians to focus on the clinical development of a small molecule therapy for the orphan disease, CLN1 Batten. This is a fatal pediatric disease caused by aberrant levels of protein palmitoylation, a reversible modification of cysteine. Palmitoylation is a common post-translational modification that can regulate protein localization, interaction and function. Circumvent is dedicated to the treatment of Batten disease, the effects of which are most pronounced in the lysosomes of neurons. Other diseases that lead to neurodegeneration may also benefit from a treatment that leads to normalization of palmitoylation levels, such as Alzheimer’s, Parkinson’s, Huntington’s and ALS and are of great interest to the company.

We are seeking a highly motivated and capable scientist to help advance our goals in the treatment of currently incurable diseases.

Job Summary

Reporting to the Chief Scientific Officer, this scientist will play a key role in driving the successful implementation of Circumvent’s research strategy. They will work with the CSO and other team members, as well as advisors, consultants, academic collaborators and CROs to achieve the broader goals of the company. These include helping to move the current lead candidate to the clinic for the treatment of CLN1 Batten disease, as well as to identify and validate other therapeutic indications that would benefit from the same molecular intervention. This position therefore provides the opportunity to develop and utilize skills in pre-clinical development as well as to establish and lead scientific programs in disease target and biomarker discovery and validation.

The team is not co-located and therefore works remotely. While this position is intended as full time, part time may be possible as well.

Essential Functions

• Be a major contributor to defining and developing the overall research strategy • Identify and recruit subject experts to validate approach and/or establish research collaborations • Take ownership of multiple research projects with outside academic partners and contract research organizations • Responsible for guiding experimental design for each managed project • Reporting to senior management on project design, status, results, conclusions and next steps • Manage resources and timelines to achieve overall goals of the company • Work closely with senior management to ensure research plans and strategies are integrated across the company • Grant applications, publishing results and patenting discoveries are all strongly encouraged and supported

Education, Experience and Skills Requirements

• PhD in a relevant scientific field such as biochemistry, molecular biology or cell biology • 3-5 years of experience in a life sciences company, preferably in drug discovery or development • Strong senior stakeholder engagement and collaboration skills • Ability to advance the goals of the company while working with senior academic collaborators and advisors • Experience in developing and implementing a scientific strategy and putting in place activities that drive results • Excellent communication, writing and relationship-building skills, with an ability to prioritize, negotiate, and work with a variety of internal and external stakeholders • Intellectual curiosity, integrity and ability to succeed in an entrepreneurial environment • Proven ability to create, implement and improve processes • Strong project management and execution skills; able to manage competing priorities • Detail oriented and highly organized • Reputation for integrity and dedicated work ethic with desire for ownership of process and product success

Circumvent is an equal opportunity employer

Technology

We are seeking a PhD level Research Scientist/Program Manager, reporting to the Chief Scientific Officer, who will play a key role in driving the successful implementation of Circumvent’s research strategy. They will work with the CSO and other team members, as well as advisors, consultants, academic collaborators and CROs to achieve the broader goals of the company. These include helping to move the current lead candidate to the clinic for the treatment of CLN1 Batten disease, as well as to identify and validate other therapeutic indications that would benefit from the same molecular intervention. This position therefore provides the opportunity to develop and utilize skills in pre-clinical development as well as to establish and lead scientific programs in disease target and biomarker discovery and validation.

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